In these lectures I review, in as much pedagogical way as possible, various theoretical ideas and motivation for violation of CPT invariance in some models of Quantum Gravity, and discuss the relevant phenomenology. Since the subject is vast, I pay particular emphasis on the CPT Violating decoherence scenario for quantum gravity, due to space-time foam. In my opinion this seems to be the most likely scenario to be realised in Nature, should quantum gravity be responsible for the violation of this symmetry. In this context, I also discuss how the CPT Violating decoherence scenario can explain experimental “anomalies” in neutrino data, such as LSND results, in agreement with the rest of the presently available data, without enlarging the neutrino sector.
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