MOLECULAR BIOLOGIC ACTTVTIY OF RECEPTOR TYROSINE KINASES IN CANINE CANCER

摘要

Cancer is a disease characterized by dysregulated growth, abridged cell death, and enhanced cell migration, invasion and angiogenesis. While the molecular mechanisms responsible for conferring this phenotype are very diverse, one of the classes of molecule that has been receiving a great deal of recent attention as a potential target for therapy are the receptor tyrosine kinases (RTKs). These are cellular receptors for extracellular growth factors that facilitate communication from the extracellularmilieu to the cell interior, mediating functions such as growth, survival, invasion and angiogenesis. A panoply of different RTKs are expressed by almost all tumor cells, but they can play variable roles in the pathogenesis of the disease.