ANTIGEN-SPECIFIC IMMUNE RESPONSE OF PIGLETS TO EXPERIMENTAL INFECTION WITH MYCOBA CTERIUM A VIUM SSP. A VIUM AND MYCOBA CTERIUMAVIUM SSP. HOMINISSUIS

摘要

Mycobacterium avium subsp. avium (MAA) and Mycobacterium avium subsp. hominissuis (MAH) are members of the Mycobacterium avium complex (MAC) which are widely distributed in the environment and have been isolated from many avian and mammalian species (Biret et al., 2005). MAA is characterized by the presence of the insertion sequences IS901+, IS 1245 and it is a primary pathogen of avian tuberculosis which is commonly found in wild and domestic animals, but rarely in humans. MAH isolates (IS901-, IS 1245+) originate particularly from the environment and are less virulent for birds (Pavlik et al., 2000; Mijs et al., 2002; Thregerstrom et al., 2005). On the other hand, MAH isolated from livestock represent s a potential source of infection for man (Mobius et al., 2006).