Necrotizing soft tissue infections caused by aerobic, anaerobic and mixed bacterial floras are a still increasing problem in surgical and medical practice. They occur with increasing frequency and seriousness,especially in immune-compromised patients.The clinical picture can vary considerably from patient to patient. Treatment is difficult, often irrational and very often "one step behind the facts," because early recognition is difficult and etiology, bacteriology, and the clinical course are sometimes not well understood or expected to evolve in a different and more favourable way. Hyperbaric Oxygen treatment (HBOT) is a highly controversial issue in the literature.Considerable morbidity occurs in these diseases and the mortality can be very high, from 20% up to 70 or 80%.
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