Development, Optimization and Characterization of Nanoparticle Drug Delivery System of Cisplatin

摘要

Purpose: Polymeric nanoparticles are frequently employed for drug delivery systems to perform a sustained release behavior of incorporated drug. These polymeric nanoparticles can be used for site specific targeting of encapsulated drug. The objective of present study was to develop a poly (lactide-co-glycolide) (PLGA) nanoparticles drug delivery system of anticancer drug cisplatin with higher therapeutic efficacy, lesser side effects, and with further development to advances in targeted chemotherapy. PLGA nanoparticles were prepared by double emulsion solvent evaporation method and characterized by their morphology, size, polydispersity index, zeta potential, drug encapsulation efficiency and in-vitro drug release in phosphate buffer saline (pH 7.4). The influences of several process parameters on the nanoparticles were observed. The results obtained from studies showed that nanoparticles developed in this study could be the nanoparticles for application in the controlled delivery of cisplatin for cancer therapeutics and may be considered promising in targeted therapy of cancer.