INFLUENCE OF INJECTION PRESSURES UP TO 100MPa AND VESSEL PRESSURES ABOVE THE CRITICAL POINT ON THE PARTICLE FORMATION IN A SUPERCRITICAL ANTISOLVENT PROCESS

摘要

The supercritical antisolvent (SAS) process is used to generate particles in the micro- and nanometer scale with a defined size, a narrow size distribution, and a defined morphology. A liquid solution of a solvent and a solute is injected into a supercritical fluid which acts as an antisolvent. By varying the process parameters such as pressure, temperature, type of solvent, solute concentration, and the flow rate ratio of solution and antisolvent the properties of the produced particles can be strongly influenced.