Reconstructing an Inversion History in the Anopheles Gambiae Complex

摘要

The phylogenetic relationships among the members of species complexes can be inferred from the distribution of fixed inversions if outgroup arrangements are known. The Anopheles gambiae complex consists of seven African mosquito species that can be differentiated based on ten fixed inversions. However, the phylogenetic relationships among the members remain unclear. This paper demonstrates that physical maps of the outgroup species A. funestus and A. stephensi can be used for determining ancestral chromosome arrangements in the A. gambiae complex. Gene order comparisons have been performed using the Multiple Genome Rearrangements (MGR) and Sorting Permutation by Reversals and block-INterchanGes (SPRING) programs. The analysis has identified the chromosomal arrangements which are likely to be the ancestral in the complex.