Narasin belongs to the polyether monocarboxylic acid class of ionophores produced by Streptomyces aureofaciens strain NRRL 8092. Narasin is composed of 96% narasin A, 1% narasin B, 2% narasin D and 1% narasin I. Narasin A has the major activity (85%).The biological activity of narasin is based on its ability to form lipid-soluble and dynamically reversible complexes with cations. Narasin functions as a carrier of these ions, mediating an electrically neutral exchange-diffusion type of ion transportacross membranes. The resultant changes in transmembrane ion gradients and electrical potentials produce critical effects on cellular function and metabolism of coccidia. Narasin is effective against sporozoites and early and late asexual stages of coccidia infections in broiler chickens, caused by Eimeria acervulina, E. brunetti, E. maxima, E. mivati, E. necatrix and E. tenella.
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