MS ANALYSIS OF PROTEIN INTERACTIONS RELEVANT FOR THE BIOSYNTHESIS OF APE

摘要

Polyketides are a large class of biologically active and structurally diverse compounds. They are synthesized by polyketide synthases (PKSs), classified as type I, II and III enzymes. The Aryl-polyene ester (APE) system is a PKS type II-like system, where ten unbound proteins are involved, but the exact process of the biosynthesis of APEs is mostly unknown [1,2]. Here we report our current results of protein interactions in the synthesis of APE.