DEVELOPMENT OF A SIMPLE MULTI-RESIDUE DETERMINATION METHOD OF 80 VETERINARY DRUGS IN FISH TISSUES BY LIQUID CHROMATOGRAPHY COUPLED TO QUADRUPOLE ORBITRAP MASS SPECTROMETRY

摘要

There is no doubt that veterinary drugs are very important for aquaculture. But inappropriate and commonly subtherapeutic use of veterinary drugs may result in the presence of drug residues in the fish tissues even food products. Most of the published multi-residues detection methods commonly employed the LC-triple-quadrupole tandem MS techniques, which requires extensive compound-dependent parameter optimization. And due to the great differences in the physicochemical properties of the various targets, we need an appropriate extraction procedure to ensure that all compounds can be extracted effectively. On the other hand, protein, fat and many other interferences are abundant in fish. There is an effective clean-up procedure still needed to eliminate background matrix interferences.