SEPARATION OF ISOMERS WITH ULTRA-HIGH-RESOLUTION ION MOBILITY SPECTROMETRY

摘要

In drift tube ion mobility spectrometry (IMS), ions are driven through a drift tube by a homogenous electric ?eld and collide with neutral drift gas molecules. The separation mainly depends on the ion-molecule collision cross section (CCS). Therefore, in more and more applications IMS are used for pre-separation of isomers that cannot be distinguished by their mass-to-charge ratio (m/z) in mass spectrometers (MS). One major bene?t of IMS is the fast separation within a few milliseconds revealing the CCS.