Identification of viral phosphorylation in human immunodeficiency viruses

摘要

In the preliminary results, we have identified 39 phosphorylation sites in Gag, Gap-Pol polyprotein and pvu with 99% confidence using localization of probability score in HIV-1. In the comparison with in silico phosphorylation site prediction tools, eight confident phosphorylation sites identified by mass spectrometry were also found in in silico predictions. We now further investigate these roles of phosphorylation sites and map the phosphorylation sites in SIV as well as extend our investigations in different HIV-1 clades, which eventually will help us to understand the primary HIV-1 infections and vaccine.