The aim of the present paper is to provide a comprehensive analysis of coupling losses in perfluorinated (PF) multi-core polymer optical fibres (MC-POFs), which consist of groups of 127 graded-index cores. In our analysis we take into account longitudinal, transverse, and angular misalignments. We perform several experimental measurements and computer simulations in order to calculate the coupling losses for a PF MC-POF prototype.
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