ASYMMETRIC SYNTHESIS OF QUATERNARY AMINOACIDS USING THE MEMORY OF CHIRALITY OF TERTIARY AROMATIC AMIDES

摘要

Due to their biological importance, many procedures have been developed for the stereoselective synthesis of quaternary α-amino acids. Some of them apply a new principle, memory of chirality in order to use the starting α-amino acid as the only source of chirality. For instance, Kawabata has performed essentially methylation and intramolecular alkylation of various α-amino acids with high enantiomeric excesses. Carlier used the intrinsic chirality of the benzodiazepine-2-one ring to obtain α,α-dialkyl amino acids enantioselectively.