Synthesis of Bistramide A spiroketal fragment

摘要

Bistramide or bistratene A is a member of a new class of bioactive molecules isolated from the marine ascidian Lissoclinum bistratum. Recent biological studies have shown that bistramide A was able to induce a highly selective activation of a single protein kinase C (PKC) isotype S. Moreover, Kozmin has revealed that actin was acting as the primary cell receptor of the natural product. Thus, this molecule, leading to growth arrest and apotosis, emerges as a potential anti-inflammatory and anti-tumoral candidate.