Enantioselective cascade reactions are very powerful synthetic protocols for the assembly of complex architectures. The goal is to devise systems in which a single reaction event triggers the conversion of starting material to chiral intermediates of high synthetic potential that can be subsequently in situ converted into products of increasing complexity. Our current approach is to exploit a (-)-spartiene controlled enantioselective carbolithiation of 2-propenyl-phenylamines 1 to provide the lithiated chiral intermediate 2.
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