Study the effect of spironolacton in airway resistance with impulse oscillometry in patients with CHF (congestive heart failure)

摘要

Introduction: CHF is one of the most important cause of mortality and morbidity in the world.Diuretics such as spironolacton can decreases pulmonary congestion and reduce the amount of fibrosisin CHF patients.The primary end point was to assess the effect of spironolacton on airway resistance with impulseoscillometry, the secondary goal was to localize the site that may be affected more by spironolactonsMethods: It was clinical trial that 24 patients with congestive heart failure (CHF) that had functionalclass II-IV and EF< 40% ,were assessed by impulse oscillometry from October 2010 to December 2010 in sinaclinic hospital. All patients were filled questionnaire and non of them taken spironolactone before.Spironolacton was given to them and they evaluated by IOS 1month later.All data were analyzed by SPSS soft ware versed 16)Result: The age of patient was 61 ± 10 and the age of control was 57 ± 7 years old .The data of oscillometry before and after spironolacton were X5( 0.14 ± 0.05 VS 0.14 ±0.05 , P: 0.93) ,R5( 0.39 ± 0.21 VS 0.39 ±0.15 , P: 0.35) , X20(0.04 ± 0.06 VS 0.06 ±0.06 , P: 0.37) , R20(0.04 ± 0.03 VS 0.06±0.06 , P: 0.37) , Zrs (0.39 ± 0.21 VS 0.39 ±0.15 , P: 0.35).Discussion: Although there was a trend toward reduction of peripheral airway restances in CHF patientsthan controls, spirinolacton had no significant decrease on air way resitance after one month treatmentkey words: spironolacton, oscillometry, CHF .