An Automated Sample Preparation System Based on the Mixing Driven by Oscillating Magnetic Fields

摘要

Mass spectrometry has historically been used to identify and quantify proteins and peptides. However, due to the inherent complexity of the biological matrix, the necessary multi-step sample preparation process has been limited to specialized laboratories with the training and expertise to perform these time-consuming assays in a reproducible and robust manner. Magnetic particle technology is nowadays the gold standard for sample processing, allowing high sensitivity and accuracy and also automation. This automation is however limited to bulky and complex robotic systems. In this work, we introduce a new automatic sample processing platform (MagPhase, Spinomix, SA) with significantly improved performances that is based on a unique way of magnetic particles handling and efficient mixing within microfluidics environment.