Glycopeptidomics: Characterizing Global Glycoprotein and Site Heterogeneity

摘要

WGA lectin weak affinity chromatography enriches practically all glycopeptides; not just those containing terminal GlcNAc or sialic acid residues. Protein Prospector is able to identify glycoproteins and glycopeptides in an unbiased fashion at high sensitivity from ETD data. Many truncated structures are identified, which are not identified in released glycan studies. For a similar type of study in mouse, see poster Tu-427 For more details on advanced modification searching options in Protein Prospector see poster W-319.