A Comparative Study of Targeted Screening Method by LC/MS/MS and Un-targeted Screening Method by LC-TOF in Residual Pesticides Analysis

摘要

This is a preliminary comparative study of MRM-based targeted screening method and HRMS based un-targeted screening method for detection of pesticides. HRMS method on LC-TOF is an ideal approach for screening of un-limited pesticides in samples. This approach requires advanced data acquisition method and high sensitivity in full spectrum mode to detect all ions without discrimination. However, data analysis may be very challenging in picking of distorted and submerged peaks due to matrix interference of actual food samples. On the other hand, the MRM-based targeted screening approach has been increasingly adopted in food safety analysis because of its operation easiness and high reliability in detection and identification of targeted pesticides. Further studies with more quantitative comparison of the two screening approaches and their performances for different samples are needed.