ADVANCING ATTRIBUTE CONTROL OF ANTIBODIES AND ITS DERIVATIVES USING HIGH RESOLUTION ANALYTICS

摘要

Increased sensitivity is achieved across a wide range of analytes including intact mAbs, ADCs and their subunits, peptides and glycans. The Vion IMS QTof QTof is capable of achieving near isotopic resolution of proteins with a MW of ·25 kDa, yielding low ppm mass accuracies results under the routine LC/MS conditions. The improved resolution provides greater confidence in the mass measurement of large peptide/small proteins, which is critical for effective middle-down fragmentation analysis.