Structural Changes During Dimerization of the Type IV Pilin from Pseudomonas aeruginosastrain K122-4 Measured by Time-Resolved Hydrogen-Deuterium Exchange

摘要

Based on changes in hydrogen-deuterium exchange, interactions occur between the amphipathic α-helix in the dimer, as well as possible involvement of a connecting loop. The truncated helix shifts further outward in order to form the interaction required for dimerization, destabilizing the β-sheet network.