Alternating charges in the linear sequence results in a dynamic protein with a range of conformations, and a high presence of extended states (p270C-P14). Grouped like-charges in the linear sequence causes a protein to have a more collapsed structure. The ionic strength of the starting solution has different effects depending on the distribution of charges in the protein. The conformational diversity of p27-C has an effect on the p27-FL/ Cdk/ Cyclin complex.
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