Use of high resolution mass spectrometry (HRMS) for synthetic peptide and oligonucleotide mapping with data-independent acquisition

摘要

Our objective to evaluate an innovation workflow for the mapping of intact peptides and oligonucleotides. The dataindependent acquisition, Agilent AIM, was a powerful function to increase the coverage for mapping. The data processing was integrated by Agilent various softwares, like Spectrum Mill 4.0, Bioconfirm, MassHunter Qual 7.0. and PCDL manager and these tools will make easy-of-use for this type study.