Single Field Direct Drift Time to CCS Calibration for a Linear Drift Tube Ion Mobility Mass Spectrometer

摘要

A novel high speed technique is developed for calibration of the CCS domain for a linear drift IM-MS spectrometer. The technique allows fast and routine CCS measurements in a single LC run with pre/post or in-run calibration. Current technique requires to have info on both m/z and z of an ion to identify its CCS based on the CCS of two known ions and therefore it is perfectly matching IM to MS tandem instrumentation.