Discovery of Glycoprotein Signatures for Aggressive Prostate Cancer via SWATH mass spectrometry

摘要

We presented the first use of SWATH-MS for profiling the glycoproteome extracted from clinical tissues and the discovery of aggressive prostate cancer biomarkers. Our result highlights the possibility of data re-mining in the one-time acquired SWATH maps when there are more MS assays available for novel protein targets. The the combination of SPEG and SWATH-MS provides reproducible, deep, and quantitative glycoproteomic reference that can be easily reexamined, and therefore, provides a significant advance for biomarker studies.