Reconfirmation of the 'Charge-Localization Isomers' of Dibasic Acids using Another GAG Disaccharide

摘要

Our aim was simply to ascertain more than one peak tops as negative ions in the driftgram of disaccharide dibasic acids, and IMS measurement of otherwise undissolvable "charge-localization isomers" was indeed successful. On the other hand, DFT theoretical calculations well picked up even isomers of unfavorable conformers, and results of DFT and IMS are in conformity. However, complete separation of a minor peak must wait for further instrumental development.