Structure Elucidation of Formaldehyde-induced DNA-protein Crosslinks by Mass Spectrometry and NMR

摘要

Formaldehyde induced crosslinking between the amino acid and nucleoside through the methylene bridge. Cysteine, Lysine, Histine, Trptophan are involved in the crosslinking reaction in model reaction systems. Cysteine-dG, Lysine-dG and Cystein-dA adducts are main crosslinking adducts.