A Novel Whole Organ Bioscaffold with an Intact Vascular Network for Tissue Engineering and Regenerative Medicine Applications

摘要

Our results demonstrate that a novel whole organ bioscaffold system can be developed using a perfusion decellularization process. We were able to preserve the native vascular network and tissue microarchitecture within the scaffold. Cells seeded on the liver matrix remain viable and progressively organize into tissue structures in vitro and in vivo. This technology may provide new opportunities in the engineering of vascularized three-dimensional tissue structures, critical for tissue engineering and regenerative medicine applications.