Nano-imprint Lithography for the Fabrication of Injectable Stimuli-Responsive Drug Delivery Devices

摘要

We have developed top-down fabrication techniques to create highly monosdisperse biocompatible nano-devices and nano-particles. The top-down nano manufacturing approach could ensure nearly rnonodisperse population of drug carriers and precise control of triggered drug release. This could provide significantly improved alternatives to currently available diffusion/degradation controlled systems. We will develop methods to load drugs in the nano-containers, to incorporate stimuli sensitive polymeric "lids" with the nano-containers and to utilize our quartz template to use S-FIL to imprint polymer nano-particles.