Dissipative particle dynamics simulation of ibuprofen molecules distribution in the matrix of solid lipid microparticles (SLM)

摘要

Dissipative particle dynamics (DPD) simulation technique is used to simulate the distribution of ibuprofen molecules in the drug carrier of solid lipid microparticles (SLM). For the SLM with tristearin as its carrier material, ibuprofen molecules are adsorbed on the surface of the carrier and a shell-spherical structure is formed, while for the SLM made from glyceryl behenate, ibuprofen molecules distribute in the outer area of the carrier matrix. The release performance of the SLM is predicted basing on the simulated microstructure. A better sustained release of ibuprofen is expected in the glyceryl behenate SLM.