Nanofibers from Chitosan_Poly Vinyl Alcohol blend and their biological and antimicrobial properties and Process optimization using response surface methodology

摘要

Nanofibers were produced from Chitosan (Cs) in 2% acetic acid and Poly vinyl alcohol (PVA) blend in DW in 10/90, 20/80, 25/75, 50/50 mass ratio of Cs/PVA. The effect of blend ratio on the fiber formation and fiber properties has been investigated Nanofibers produced were characterized by SEM, FTIR and DSC. The response surface methodology was used to model and optimize the electrospinning parameters for the spinning of blend Chitosan_PVA nanofibers. Voltage (10_25KV) and extrusion rate of polymer solutions (0 2_1ml/hr) from nozzle were chosen as variables to control fiber diameter at same spinning distances (10cm), Fiber diameter was correlated to these variables by using a second order polynomial function. The predicted fiber diameters were in agreement with the experimental results.