Continuous flow synthesis of DNDA57 in a capillary microreactor

摘要

The liquid - liquid slug flow capillary microreactor has been shown to be a useful instrument for the enhancement of fast heat and mass transfer limited reactions [1],[2]. The ability to separate downstream liquids easily suggests that the liquid-liquid slug flow in capillaries is a powerful laboratory technique for elucidating biphasic reactions and extraction. A key feature of this type of microreactor in combination with liquid-liquid separators is the possibility to implement a counter-current or cross-flow operation mode. This reactor concept enables a constant stoichiometry and ensures constant reaction rates distributed over the entire residence time. A greater space-time yield could be therefore expected with the new reactor type. In the present work, we have developed a continuous liquid-liquid phase separator and used it together with a slug flow capillary microreactor to perform a continuous flow synthesis of DNDA57. The first results of the influence of different operation modes, co-current, counter-current and cross-flow are shown.