Physiological Role of Transverse-Axial Tubular System in Cardiac Ventricular Myocytes: A Simulation Study

摘要

Experimental data related to the transverse - axial tubular system of guinea pig and rat ventricular myocytes were incorporated into quantitative models of their electrical activity. The results of simulations suggest that activity-dependent depletion of Ca{sup}(2+) within the tubular lumen decreases the intracellular Ca{sup}(2+) load and intracellular Ca{sup}(2+) transients in both species. However, considerable species differences in the magnitude of the depletion, its frequency dependence and the resulting effect on cellular activity were observed.