Study of (99m){sup left}Tc-TRODAT-1 imaging on human brain with children autism by single photon emission computed tomography

摘要

To evaluate the application values of (99m){sup left}Tc-2β [N, N'- bis (2-mercaptoethy1) ethylenediamino] methyl, 3 β -(4-chlorophenyl) tropane (TRODAT-1) dopamine transporter (DAT) SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Ten autistic children and ten healthy controls were examined with (99m){sup left}Tc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of (99m){sup left}Tc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striatum and cerebellum [(STR-BKG)/BKG]. There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children (p=0.562) and in normal controls (p=0.573); Dopamine transporter in brain of patients with autism increased significantly than that in normal controls (p=0.017). Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT (99m){sup left}Tc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.