UTILIZATION OF FBRM IN THE CONTROL OF CSD IN A BATCH COOLED CRYSTALLIZER

摘要

Controlling crystal size distribution (CSD) is important to downstream processing and to product quality. The distribution can be characterized by a mean or dominant size and the spread about that value. Control of the distribution in a batch crystallizer, is the main topic of the present study. An experimentally based control scheme has been implemented in a system involving the batch cooling crystallization of paracetamol from ethanol solutions. In order to obtain the paracetamol CSD the chord length distribution (CLD) given by focused beam reflectance measurement (FBRM) and Lasentec software is fed to a model that calculates the CSD. After each run, sieving was done to check the accuracy of the model.