Electrochemical Deposition of Calcium Phosphate for Implant Osseointegration and Drug Release

摘要

This study is about a modification of a previously described method for electrochemical deposition of Calcium Phosphate (Ca/P) coatings on Titanium-based devices. A one pot process for ion doping of coatings and co-deposition of drugs was exploited, with the aim to trigger specific biological responses. Ca/P coatings were performed on Ti specimens via cathodic polarization route in an electrochemical bath originally proposed by Redepenning. For this study, the original solution was modified by adding Mg_3O_8P_2·8H_2O, MgHPO_4·3H_2O or Ag_3PO_4. The obtained coatings were evaluated in terms of morphological properties, crystallographic phases and solubility. Results showed an effective incorporation of Mg or Ag ions in brushite coatings, without any major effects on morphology or cristallinity of the coatings. On the contrary, some effect on deposition kinetic was noticed. Moreover, dissolution kinetic behaviour was also studied in physiological-like environments for both as deposited and converted coatings, showing a different dissolution rate depending on crystallographic phase. Cathodic polarization was found a simple and powerful method to obtain bone contact surface tailored coatings.