N-FORMYL PEPTIDE RECEPTOR-LIKE 1 OF THE NEUTROPHILS IN THE AA-AMYLOIDOSIS TISSUES IS LESS STAINED

摘要

N-formyl peptide receptor-like 1 (fPRL1) is considered as a family member of calcium mobilizing G protein-coupled receptors for bacterial N-formyl peptides in phagocyte cells such as neutrophils and monocytes, which mediates chemotaxis, degranuiation and respiratory burst (1), fPRL1 is also considered as an agonistic receptor for either mitochondrial proteins of damaged host cells or invading pathogens (1). Therefore, fPRL1 is mainly involved in the host defense against infective organs and in the clearance of damaged cells (1).