Recent Activities on Innovative Radionuclide Production for Metabolic Radiotherapy and Pet and on Relevant Experimental and Evaluated Nuclear Data

摘要

Activities and relevant results are discussed concerning the radionuclide production for medical applications brought up recently at LASA-INFN Laboratory in collaboration with ENEA, Division for Advanced Physical Technologies. Particularly, measurements of spectrometric values and of radionuclidic, radiochemical and chemical purities, by analytical and radioanalytical techniques, are discussed. Concerning the excitation functions relevant to the nuclear reactions involved in the radionuclide production, evaluated nuclear data are discussed as they have been produced through appropriate comparisons of present and other available and critically selected experimental values with main reliable model calculations. In particular, NCA radionuclides, for uses in metabolic radiotherapy and PET, have been investigated, such as: i) ~186gRe, produced by ~186W(p,n) reaction (for bone metastases pain palliation by 1.1 MeV beta- metabolic radiotherapy and SPECT imaging), ii) NCA 211 At/ 211gPo, produced by ~209Bi(alpha,2n) reaction, with internal spike of y emitter 210At from ~209Bi(alpha,3n) reaction, for high-LET radiotherapy and immunoradiotherapy, and iii) ~103Pd, produced by the alternative ~103Rh(d,2n) reaction route, as a commonly used radioisotope for therapeutic treatments.Most significant results are also referred as from recent years activities at the above Institutes.