Premalignant Breast Disease: Anatomic Lesions and Hormonal Associations

摘要

Breast cancer (BC) risk associations are many, and specific patterns of hyperplastic lesions, as revealed in biopsy tissue, are among the most widely accepted. A review of these lesions is presented in this chapter, along with their magnitude of BC risk and regional implications in women. In this chapter, the term ''premalignant' is used broadly, and indicate by the term 'disease' that the risk implications are of a magnitude that may have possible practical importance for an individual woman. Many of the risk associations that are well-known are just above 1.0. An age-corrected relative risk (RR) of 50% elevation in a period of 10-15 years after biopsy, has been adopted as a reference point to make suggested quantitative references (1) (ie., slight = 1.5-2.0 x; moderate - 4.0-5.0 x). Particularly important, and not recognized in the initial, formal epidemiologic studies of hyperplastic lesions in the breast, is the varied implication for site(s) and type of later BC presentation.