Optimal Process Synthesis for the Production of Multiple Recombinant Proteins

摘要

This work presents an optimization model for the synthesis of bioprocesses that contain batch and semi-continuous items that can be duplicated and operated either in or out of phase. The model minimizes the overall plant cost and is composed of sizing and cycle time constraints, multiple-choice constraints for host and stage selection as well as production targets for each product are enforced in the model. Results on a 15-stage plant that processes four products under four different hosts show that the nature of the problem greatly affects host selection, plant structure and selection of unit operations.