FORMULATION DEVELOPMENT OF pH BASED COLON SPECIFIC MICROSPHERES BY SPRAY DRYING

摘要

Celecoxib, is a COX-2 specific NSAID with an ever-increasing spectrum of pharmacological activity. It is currently indicated for the treatment of osteoarthritis, rheumatoid arthritis, acute pain and Familial Adenomatous Polyposis (FAP).. In recent years, colon targeted delivery systems have attracted a great deal of interest for the local treatment of a variety of bowel diseases In view of the reported role of celecoxib in management of FAP and thus chemoprevention of colon cancer, a need was felt to develop a colon specific delivery system which could contribute to enhance the performance of the drug, reduce its dose in FAP (i.e. 400 mg B.D.) and thereby increase patient compliance.