EFFECT OF MOLECULAR WEIGHT AND DEGREE OF DEACETYLATION ON CHITOSAN-DNA NANOPARTICLES

摘要

Mw and DD of chitosan affected cellular uptake of chitosan-DNA nanoparticles and the ability of chitosan to protect the DNA against nucleases. Lack of protection and poor cellular uptake led to low in vitro transfection efficiency for nanoparticles prepared with chitosan of low Mw or low DD.