Automated QT/RR Analysis Based on Selective Beat Averaging Applied to Electrocardiographic Holter 24 H

摘要

The study of QT/RR relationship is important for the clinical evaluation of possible risk of acquired or congenital ventricular tachyarrhythmias, predisposing to life-threatening arrhythmias. To improve the signal-to-noise ratio and obtain automated and reliable QT measurements from Holter ECG 24 h, a new approach based on selective beats averaging was applied. A total of 102 healthy subjects (range 30-75 years, 53 women, 52.8 ±11.0 years, and 49 men, 56.6 ±11.8years) were studied to obtain QT/RR normality curves (±2SD around mean value) separately for day and night-time. Gender-related and circadian differences in the QT/RR relation were noticed, showing the potential utility and application of this analysis to derive physiological observations on repolarization mechanisms.