Indirect Cytotoxicity Evaluation of Soluble Silica, Calcium, Phosphate and Silver Ions

摘要

New classes of materials are being designed to interact specifically with mammalian cells to control their behavior and subsequently direct the repair or regeneration of organ specific tissues. It has been reported that ionic products released by melt-derived 45S5 Bioglass~R activated several families of genes that induced new bone formation. In this study, the cytotoxicity of soluble silica, calcium, silver and phosphate ions on osteoblasts is investigated. It is concluded that the amount of soluble ions, such as silica, calcium, phosphate and silver, in the culture medium can influence the cellular viability in both a positive and negative manner and a combination of Si and Ca ions induce cell proliferation.