α-Tricalcium Phosphate Cements and the Granules to Dental Pulp and Periapical Tissue

摘要

α-tricalcram phosphate (α-TCP) granules and α-TCP cements kneaded with high or low concentration of organic acid solution were respectively placed on the dental pulp surface after pulp extirpation to estimate pulp tissue responses and hard tissue formation in rat mandibular first molar canals. The tissue responses in the residual pulp in the middle and apical portion of the root canals and periapical area were histopathologically estimated 1, 3 and 5 weeks postoperatively. α-TCP granules and α-TCP cement kneaded with a low concentration of citric acid solution induced acute inflammation in the pulp tissue. α-TCP cements kneaded with high concentration of citric acid solution induce hard tissue deposition at the apical portion of root canal. It is concluded that fine granules dispersed from the material in the tissue, even though it is a biocompatible material, caused inflammatory responses.