A Theoretical Model on Optical Clearing of biological Tissue with Chemical Active Agents

摘要

Quantitative analysis of biological tissue responding to chemical active agents (CAA) that osmotically transport across tissue poses a challenge task for modem biomedical technologies. It is known that the application of osmotically CAA to biotissue such as skin, muscle and gastrointestinal tracts can make the biological tissue transparent. Such osmotic action of agents to the biological tissue have not yet been understood or quantified in a way that degree of optical clearing to the tissue is predictive. We consider that optical properties of biological tissue are altered due to the changes of micro-structures and scattering constituents after CAA permeates into tissue. The changes of optical properties of biological tissue are due to the refractive indices matching between the particles (scatterers) with high refractive index and the ground substances leading to reduce scattering of tissue. The main reasons are that permeated CAA with higher refractive index than the ground substances of tissue make the refractive index of ground substances of tissue higher by the enhancement of the permeated concentration. In this paper, we described a theoretical model based on the collimated transmittance changes of light penetrating fibrous tissue after the CAA administrates with different concentration.