Efficacy of Gabapentin in the Prophylaxis of Intractable Chronic Migraine

摘要

We performed a prospective analysis of 22 patients who presented intractable chronic migraine with or without aura and received Gabapentin for prophylaxis during 16 weeks. The primary efficacy measure was a comparison of mean 28-day migraine rates during the study. Secondary efficacy measures included comparison of percentage of patients with 50% reduction in migraine frequency. The group included 18 female and 4 male, aged 21 to 54 years. The history of migraine in these patients was 12 years, with a range of crisis from 3-5 per week to daily or near daily. All patients were on more than one concurrent prophylactic medication. The mean dose of Gabapentin was 1880 mg/d. After the study period, almost 87% of patients were improved or much improved and 13.6% reported no change. Gabapentin was well tolerated. No one discontinued the treatment.