Nalmefene hydrochloride has been micronized using Supercritical AntiSolvent precipitation technique. Experiments have been performed using a laboratory-scale apparatus, and on a pilot-scale plant. Ethyl alcohol (EtOH) has been used as liquid solvent. The particles produced using the two plants have the same morphology and comparable size (from 0.5 to 2 mm). The micronized product has been characterized using X-ray analysis, to verify the influence of the micronization process on the final product properties. XRD analysis demonstrated that it is possible to obtain amorphous or crystalline precipitates, depending on the process conditions.
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