SOLUBILITY OF CHOLESTEROL IN SUPERCRITICAL CARBON DIOXIDE

摘要

Supercritical fluid (SCF) extraction offers a good alternative to the current methods of extraction that normally involve the use of organic solvents. To perform this technique it is very important to know the solubility of the drug in the supercritical fluid, usually carbon dioxide. Several set of solubility data of cholesterol in supercritical CO_2 have been reported in literature: however there is a considerable inconsistency in the experimental results. In this work, the solubility of cholesterol in supercritical carbon dioxide at 313, 323 and 333 K and at pressures between 110-170 bar has been determined. The experimental data obtained have been compared with literature data and correlated with the Peng Robinson and the PHSC equations of state.